PDB entry 6cz4

View 6cz4 on RCSB PDB site
Description: Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
Class: Transferase/Transferase Inhibitor
Keywords: Protein kinase, PTK6, Transferase-Transferase Inhibitor complex
Deposited on 2018-04-07, released 2018-06-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-06-20, with a file datestamp of 2018-06-15.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein-tyrosine kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK6, BRK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13882 (Start-263)
      • conflict (4)
    Domains in SCOPe 2.07: d6cz4a_
  • Heterogens: FKY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6cz4A (A:)
    gsddaerpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqam
    kklrhkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaeg
    mcylesqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapeal
    srghystksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhkl
    mltcwcrdpeqrpcfkalrerlss
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cz4A (A:)
    daerpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkkl
    rhkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaegmcy
    lesqnyihrdlaarnilvgentlckvgdfglarlikedvylshpykwtapealsrghyst
    ksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltcwcr
    dpeqrpcfkalrerlss