PDB entry 6cqd

View 6cqd on RCSB PDB site
Description: Crystal structure of HPK1 in complex with ATP analogue (AMPPNP)
Class: transferase
Keywords: Protein kinase, TRANSFERASE
Deposited on 2018-03-14, released 2018-12-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-12-19, with a file datestamp of 2018-12-14.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (2-293)
      • conflict (165)
      • conflict (171)
      • expression tag (294)
    Domains in SCOPe 2.07: d6cqda1, d6cqda2
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (Start-293)
      • conflict (165)
      • conflict (171)
      • expression tag (294)
    Domains in SCOPe 2.07: d6cqdb1, d6cqdb2
  • Heterogens: ANP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6cqdA (A:)
    gsdvvdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstl
    qkeililktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcr
    evlqglaylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpywm
    apevaavalkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlke
    kgkwsaafhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkngns
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cqdA (A:)
    dvvdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvdddvstlqkeili
    lktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgl
    aylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpywmapevaa
    valkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsa
    afhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkng
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6cqdB (B:)
    gsdvvdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstl
    qkeililktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcr
    evlqglaylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpywm
    apevaavalkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlke
    kgkwsaafhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkngns
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cqdB (B:)
    vdpdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkei
    lilktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlq
    glaylhsqkkihrdikganilindagevrladfgisaqigaelarrlefigtpywmapev
    aavalkggynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkw
    saafhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkng