PDB entry 6cms

View 6cms on RCSB PDB site
Description: Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: protein tyrosine phosphatase, src homology domain 2, inactive state, active mutant, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2018-03-06, released 2018-11-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (78)
    Domains in SCOPe 2.07: d6cmsa1, d6cmsa2, d6cmsa3
  • Heterogens: 5OD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cmsA (A:)
gsgmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiq
ntgdyydlyggekfatlaklvqyymehhgqlkekngdvielkyplncadptserwfhghl
sgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqel
kydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskla
ettdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdp
nepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmtt
kevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwq
yhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilid
iirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrri

    Sequence, based on observed residues (ATOM records): (download) 
    >6cmsA (A:)
tsrrwfhpnitgveaenllltrgvdgsflarpspgdftlsvrrngavthikiqntgdyyd
lyggekfatlaklvqyymehhgqlkekngdvielkyplncadptserwfhghlsgkeaek
lltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkydvggg
erfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskkqgfweefe
tlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhsdyinaniimpekksyiat
qgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvke
saahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesim
dagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaq
yrfiymavqhyietlqr