PDB entry 6cmr

View 6cmr on RCSB PDB site
Description: Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: protein tyrosine phosphatase, src homology domain 2, inactive state, active mutant, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2018-03-06, released 2018-11-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (78)
    Domains in SCOPe 2.07: d6cmra1, d6cmra2, d6cmra3
  • Heterogens: 5OD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6cmrA (A:)
    gsgmtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiq
    ntgdyydlyggekfatladlvqyymehhgqlkekngdvielkyplncadptserwfhghl
    sgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqel
    kydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskla
    ettdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdp
    nepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmtt
    kevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwq
    yhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilid
    iirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrri
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cmrA (A:)
    tsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgd
    yydlyggekfatladlvqyymehhgqlkedvielkyplncadptserwfhghlsgkeaek
    lltekgkhgsflvresqshpgdfvlsvrtgddsndgkskvthvmircqelkydvgggerf
    dsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqq
    qeckllysrkegqrqenknknryknilpfdhtrvvlhsdyinaniimpekksyiatqgcl
    qntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaah
    dytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagp
    vvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfi
    ymavqhyietlqrr