PDB entry 6cmq

View 6cmq on RCSB PDB site
Description: Structure of human SHP2 without N-SH2 domain
Class: hydrolase
Keywords: protein tyrosine phosphatase, src homology domain 2, open state, active mutant, HYDROLASE
Deposited on 2018-03-06, released 2018-11-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cmqa1, d6cmqa2
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cmqb1, d6cmqb2
  • Chain 'C':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cmqc1, d6cmqc2
  • Chain 'D':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cmqd1, d6cmqd2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6cmqA (A:)
    gsgdptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesnd
    gkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrin
    aaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrykni
    lpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfw
    rmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelk
    lskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsag
    igrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyi
    etlqrri
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cmqA (A:)
    dptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtkskvthvmircq
    elkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsk
    laedkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdp
    nepvsdyinaniimpkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcv
    kywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgv
    psdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdi
    dvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6cmqB (B:)
    gsgdptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesnd
    gkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrin
    aaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrykni
    lpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfw
    rmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelk
    lskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsag
    igrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyi
    etlqrri
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cmqB (B:)
    ptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrkvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklvkq
    gfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyi
    naniimpepkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpde
    yalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpgg
    vldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpkti
    qmvrsqrsgmvqteaqyrfiymavqhyietlqrr
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6cmqC (C:)
    gsgdptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesnd
    gkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrin
    aaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrykni
    lpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfw
    rmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelk
    lskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsag
    igrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyi
    etlqrri
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cmqC (C:)
    ptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtthvmircydvggg
    erfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklgfweefet
    lqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpe
    fkpkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkey
    gvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfle
    evhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsq
    rsgmvqteaqyrfiymavqhyietlqrr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6cmqD (D:)
    gsgdptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesnd
    gkskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrin
    aaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknrykni
    lpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfw
    rmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelk
    lskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsag
    igrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyi
    etlqrri
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cmqD (D:)
    dptserwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtskvthvmircqe
    lkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskl
    aevkqgfweefetlqqqysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyi
    naniimpefksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdey
    alkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggv
    ldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiq
    mvrsqrsgmvqteaqyrfiymavqhyietlqr