PDB entry 6cjg

View 6cjg on RCSB PDB site
Description: Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Oxidoreductase, oxidoreductase inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2018-02-26, released 2018-05-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-23, with a file datestamp of 2018-05-18.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cjga_
  • Heterogens: FMN, ORO, F51, GOL, SO4, ZWI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6cjgA (A:)
    gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
    giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
    glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
    vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
    kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
    vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
    dhrrleaghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cjgA (A:)
    derfyaehlmptlqglldpesahrlavrftslgllprfqdsdmlevrvlghkfrnpvgia
    agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
    vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
    pnlqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgli
    vtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqd
    alekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr