PDB entry 6cis

View 6cis on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG047
Class: transcription/inhibitor
Keywords: Kinase, Inhibitor, BRD4, TRANSCRIPTION, TRANSCRIPTION-INHIBITOR complex
Deposited on 2018-02-25, released 2018-08-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 1.51 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-124)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6cisa1, d6cisa2
  • Heterogens: X26, EDO, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6cisA (A:)
    smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
    ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
    nelpt