PDB entry 6cie

View 6cie on RCSB PDB site
Description: Structure of human endothelial nitric oxide synthase heme domain in complex with N-(1-(2-(Ethyl(methyl)amino)ethyl)-1,2,3,4-tetrahydroquino-lin-6-yl)thiophene-2-carboximidamide
Class: oxidoreductase
Keywords: Nitric oxide synthase inhibitor complex heme enzyme, OXIDOREDUCTASE
Deposited on 2018-02-23, released 2018-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, endothelial
    Species: Homo sapiens [TaxId:9606]
    Gene: NOS3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ciea_
  • Chain 'B':
    Compound: Nitric oxide synthase, endothelial
    Species: Homo sapiens [TaxId:9606]
    Gene: NOS3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cieb_
  • Chain 'C':
    Compound: Nitric oxide synthase, endothelial
    Species: Homo sapiens [TaxId:9606]
    Gene: NOS3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ciec_
  • Chain 'D':
    Compound: Nitric oxide synthase, endothelial
    Species: Homo sapiens [TaxId:9606]
    Gene: NOS3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6cied_
  • Heterogens: HEM, H4B, 7R2, BTB, ZN, GOL, CL, GD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cieA (A:)
apasllppapehsppsspltqppegpkfprvknwevgsitydtlsaqaqqdgpctprrcl
gslvfprklqgrpspgppapeqllsqardfinqyyssikrsgsqaheqrlqeveaevaat
gtyqlreselvfgakqawrnaprcvgriqwgklqvfdardcrsaqemftyicnhikyatn
rgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqhgwt
pgngrfdvlplllqapdeppelfllppelvlevplehptlewfaalglrwyalpavsnml
leigglefpaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdkaav
einvavlhsyqlakvtivdhhaatasfmkhleneqkarggcpadwawivppisgsltpvf
hqemvnyflspafryqpdpw

    Sequence, based on observed residues (ATOM records): (download) 
    >6cieA (A:)
fprvknwevgsitydtlsaqaqqdgpctprrclgslvfprpeqllsqardfinqyyssik
rsgsqaheqrlqeveaevaatgtyqlreselvfgakqawrnaprcvgriqwgklqvfdar
dcrsaqemftyicnhikyatnrgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdg
svrgdpanveitelciqhgwtpgngrfdvlplllqapdeppelfllppelvlevplehpt
lewfaalglrwyalpavsnmlleigglefpaapfsgwymsteigtrnlcdphryniledv
avcmdldtrttsslwkdkaaveinvavlhsyqlakvtivdhhaatasfmkhleneqkarg
gcpadwawivppisgsltpvfhqemvnyflspafryqpdpw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6cieB (B:)
apasllppapehsppsspltqppegpkfprvknwevgsitydtlsaqaqqdgpctprrcl
gslvfprklqgrpspgppapeqllsqardfinqyyssikrsgsqaheqrlqeveaevaat
gtyqlreselvfgakqawrnaprcvgriqwgklqvfdardcrsaqemftyicnhikyatn
rgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqhgwt
pgngrfdvlplllqapdeppelfllppelvlevplehptlewfaalglrwyalpavsnml
leigglefpaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdkaav
einvavlhsyqlakvtivdhhaatasfmkhleneqkarggcpadwawivppisgsltpvf
hqemvnyflspafryqpdpw

    Sequence, based on observed residues (ATOM records): (download) 
    >6cieB (B:)
kfprvknwevgsitydtlsaqaqqdgpctprrclgslvfpapeqllsqardfinqyyssi
krsgsqaheqrlqeveaevaatgtyqlreselvfgakqawrnaprcvgriqwgklqvfda
rdcrsaqemftyicnhikyatnrgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqd
gsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeppelfllppelvlevplehp
tlewfaalglrwyalpavsnmlleigglefpaapfsgwymsteigtrnlcdphryniled
vavcmdldtrttsslwkdkaaveinvavlhsyqlakvtivdhhaatasfmkhleneqkar
ggcpadwawivppisgsltpvfhqemvnyflspafryqpdpw

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6cieC (C:)
apasllppapehsppsspltqppegpkfprvknwevgsitydtlsaqaqqdgpctprrcl
gslvfprklqgrpspgppapeqllsqardfinqyyssikrsgsqaheqrlqeveaevaat
gtyqlreselvfgakqawrnaprcvgriqwgklqvfdardcrsaqemftyicnhikyatn
rgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqhgwt
pgngrfdvlplllqapdeppelfllppelvlevplehptlewfaalglrwyalpavsnml
leigglefpaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdkaav
einvavlhsyqlakvtivdhhaatasfmkhleneqkarggcpadwawivppisgsltpvf
hqemvnyflspafryqpdpw

    Sequence, based on observed residues (ATOM records): (download) 
    >6cieC (C:)
fprvknwevgsitydtlsaqaqqdgpctprrclgslvfpapeqllsqardfinqyyssik
rsgsqaheqrlqeveaevaatgtyqlreselvfgakqawrnaprcvgriqwgklqvfdar
dcrsaqemftyicnhikyatnrgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdg
svrgdpanveitelciqhgwtpgngrfdvlplllqapdeppelfllppelvlevplehpt
lewfaalglrwyalpavsnmlleigglefpaapfsgwymsteigtrnlcdphryniledv
avcmdldtrttsslwkdkaaveinvavlhsyqlakvtivdhhaatasfmkhleneqkarg
gcpadwawivppisgsltpvfhqemvnyflspafryqpdpw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6cieD (D:)
apasllppapehsppsspltqppegpkfprvknwevgsitydtlsaqaqqdgpctprrcl
gslvfprklqgrpspgppapeqllsqardfinqyyssikrsgsqaheqrlqeveaevaat
gtyqlreselvfgakqawrnaprcvgriqwgklqvfdardcrsaqemftyicnhikyatn
rgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqhgwt
pgngrfdvlplllqapdeppelfllppelvlevplehptlewfaalglrwyalpavsnml
leigglefpaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdkaav
einvavlhsyqlakvtivdhhaatasfmkhleneqkarggcpadwawivppisgsltpvf
hqemvnyflspafryqpdpw

    Sequence, based on observed residues (ATOM records): (download) 
    >6cieD (D:)
kfprvknwevgsitydtlsaqaqqdgpctprrclgslvfpapeqllsqardfinqyyssi
krsgsqaheqrlqeveaevaatgtyqlreselvfgakqawrnaprcvgriqwgklqvfda
rdcrsaqemftyicnhikyatnrgnlrsaitvfpqrcpgrgdfriwnsqlvryagyrqqd
gsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeppelfllppelvlevplehp
tlewfaalglrwyalpavsnmlleigglefpaapfsgwymsteigtrnlcdphryniled
vavcmdldtrttsslwkdkaaveinvavlhsyqlakvtivdhhaatasfmkhleneqkar
ggcpadwawivppisgsltpvfhqemvnyflspafryqpdpw