PDB entry 6cfo

View 6cfo on RCSB PDB site
Description: human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate
Class: oxidoreductase
Keywords: thiamin pyrophosphate, acetyl phosphinate, inhibitor, pyruvate dehydrogenase, oxidoreductase
Deposited on 2018-02-15, released 2018-07-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-07-11, with a file datestamp of 2018-07-06.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • expression tag (3)
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (12-340)
      • expression tag (11)
    Domains in SCOPe 2.07: d6cfob1, d6cfob2, d6cfob3
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • expression tag (3)
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (12-340)
      • expression tag (11)
    Domains in SCOPe 2.07: d6cfod1, d6cfod2, d6cfod3
  • Heterogens: A5X, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6cfoB (B:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cfoB (B:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6cfoD (D:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cfoD (D:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni