PDB entry 6cer

View 6cer on RCSB PDB site
Description: Human pyruvate dehydrogenase complex E1 component V138M mutation
Class: oxidoreductase
Keywords: pyruvate dehydrogenase deficiency, mutation, thiamin diphosphate, metabolism, OXIDOREDUCTASE
Deposited on 2018-02-12, released 2018-07-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-07-11, with a file datestamp of 2018-07-06.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • expression tag (2-3)
      • engineered mutation (141)
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (2-330)
      • expression tag (1)
    Domains in SCOPe 2.07: d6cerb1, d6cerb2, d6cerb3
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (Start-364)
      • engineered mutation (141)
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (2-330)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6cerd1, d6cerd2, d6cerd3
  • Chain 'E':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • expression tag (3)
      • engineered mutation (141)
  • Chain 'F':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (2-330)
      • expression tag (1)
    Domains in SCOPe 2.07: d6cerf1, d6cerf2, d6cerf3
  • Chain 'G':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • expression tag (1-3)
      • engineered mutation (141)
  • Chain 'H':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (2-330)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6cerh1, d6cerh2, d6cerh3
  • Heterogens: TDP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6cerB (B:)
    gslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpis
    emgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpn
    gasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygv
    pfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinm
    rtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtga
    dvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cerB (B:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6cerD (D:)
    gslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpis
    emgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpn
    gasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygv
    pfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinm
    rtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtga
    dvpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >6cerF (F:)
    gslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpis
    emgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpn
    gasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygv
    pfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinm
    rtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtga
    dvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >6cerF (F:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6cerH (H:)
    gslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpis
    emgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpn
    gasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygv
    pfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinm
    rtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtga
    dvpmpyakilednsipqvkdiifaikktlni