PDB entry 6c9s

View 6c9s on RCSB PDB site
Description: Mycobacterium tuberculosis adenosine kinase bound to (2R,3R,4S,5R)-2-(6-([1,1'-biphenyl]-4-ylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Class: transferase/transferase inhibitor
Keywords: Nucleoside analog, Complex, Inhibitor, Structural Genomics, PSI-2, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2018-01-28, released 2019-05-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-05-01, with a file datestamp of 2019-04-26.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenosine kinase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: adoK, cbhK, MRA_2218
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c9sa_
  • Chain 'B':
    Compound: adenosine kinase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: adoK, cbhK, MRA_2218
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c9sb_
  • Heterogens: ERP, SO4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6c9sA (A:)
    mtiavtgsiatdhlmrfpgrfseqllpehlhkvslsflvddlvmhrggvagnmafaigvl
    ggevalvgaagadfadyrdwlkargvncdhvlisetahtarftcttdvdmaqiasfypga
    msearnikladvvsaigkpelviigandpeamflhteecrklglafaadpsqqlarlsge
    eirrlvngaaylftndyewdlllsktgwseadvmaqidlrvttlgpkgvdlvepdgttih
    vgvvpetsqtdptgvgdafragfltgrsaglglersaqlgslvavlvlestgtqewqwdy
    eaaasrlagaygehaaaeivavla
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c9sA (A:)
    tiavtgsiatdhlmrfpgrfseqvslsflvddlvmhrggvagnmafaigvlggevalvga
    agadfadyrdwlkargvncdhvlisetahtarftcttdvdmaqiasfypgamsearnikl
    advvsaigkpelviigandpeamflhteecrklglafaadpsqqlarlsgeeirrlvnga
    aylftndyewdlllsktgwseadvmaqidlrvttlgpkgvdlvepdgttihvgvvpetsq
    tdptgvgdafragfltgrsaglglersaqlgslvavlvlestgtqewqwdyeaaasrlag
    aygehaaaeivavl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6c9sB (B:)
    mtiavtgsiatdhlmrfpgrfseqllpehlhkvslsflvddlvmhrggvagnmafaigvl
    ggevalvgaagadfadyrdwlkargvncdhvlisetahtarftcttdvdmaqiasfypga
    msearnikladvvsaigkpelviigandpeamflhteecrklglafaadpsqqlarlsge
    eirrlvngaaylftndyewdlllsktgwseadvmaqidlrvttlgpkgvdlvepdgttih
    vgvvpetsqtdptgvgdafragfltgrsaglglersaqlgslvavlvlestgtqewqwdy
    eaaasrlagaygehaaaeivavla
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c9sB (B:)
    tiavtgsiatdhlmrfpgrfsevslsflvddlvmhrggvagnmafaigvlggevalvgaa
    gadfadyrdwlkargvncdhvlisetahtarftcttdvdmaqiasfypgamsearnikla
    dvvsaigkpelviigandpeamflhteecrklglafaadpsqqlarlsgeeirrlvngaa
    ylftndyewdlllsktgwseadvmaqidlrvttlgpkgvdlvepdgttihvgvvpetsqt
    dptgvgdafragfltgrsaglglersaqlgslvavlvlestgtqewqwdyeaaasrlaga
    ygehaaaeivavl