PDB entry 6c4d

View 6c4d on RCSB PDB site
Description: Structure based design of RIP1 kinase inhibitors
Class: Transferase/Transferase Inhibitor
Keywords: HUMAN RIPK1 KINASE, CELL CYCLE, Transferase-Transferase Inhibitor complex
Deposited on 2018-01-11, released 2018-03-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-296)
      • conflict (36)
      • conflict (129)
      • conflict (235)
      • conflict (242)
    Domains in SCOPe 2.08: d6c4da_
  • Chain 'B':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-296)
      • conflict (36)
      • conflict (129)
      • conflict (235)
      • conflict (242)
    Domains in SCOPe 2.08: d6c4db_
  • Chain 'C':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-296)
      • conflict (36)
      • conflict (129)
      • conflict (235)
      • conflict (242)
    Domains in SCOPe 2.08: d6c4dc_
  • Chain 'D':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546
      • conflict (36)
      • conflict (129)
      • conflict (235)
      • conflict (242)
    Domains in SCOPe 2.08: d6c4dd_
  • Heterogens: EJP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6c4dA (A:)
ggsgqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehn
ealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgr
iileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelr
evdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqql
imaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6c4dA (A:)
nvikmkssdflegfgkvslafhrtqglmimktvykgpnciehnealleeakmmnrlrhsr
vvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgv
ihkdlkpenilvdndfhikiadlglasfkmwsklnneehngtlyymapehlndvnakpte
ksdvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklc
weanpearptfpgieekfrpfylsqle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6c4dB (B:)
ggsgqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehn
ealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgr
iileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelr
evdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqql
imaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6c4dB (B:)
lnvikmkssdflesaelkvslafhrtqglmimktvykgpnciehnealleeakmmnrlrh
srvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgk
gvihkdlkpenilvdndfhikiadlglasfkmwsklnnegtlyymapehlndvnakptek
sdvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcw
eanpearptfpgieekfrpfylsqle

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6c4dC (C:)
ggsgqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehn
ealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgr
iileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelr
evdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqql
imaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6c4dC (C:)
ikmkssdflesaeldkvslafhrtqglmimktvykgphnealleeakmmnrlrhsrvvkl
lgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkd
lkpenilvdndfhikiadlglasfkmwsklngtlyymapehlndvnakpteksdvysfav
vlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearp
tfpgieekfrpfylsqle

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6c4dD (D:)
ggsgqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehn
ealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgr
iileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelr
evdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqql
imaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

    Sequence, based on observed residues (ATOM records): (download) 
    >6c4dD (D:)
mslnvikmkssdflesagkvslafhrtqglmimktvykgpnciehnealleeakmmnrlr
hsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhg
kgvihkdlkpenilvdndfhikiadlglasfkmwsklnnegtlyymapehlndvnakpte
ksdvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklc
weanpearptfpgieekfrpfylsql