PDB entry 6c2y

View 6c2y on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG257142
Class: TRANSFERASE/Signaling Protein
Keywords: TRANSFERASE-Signaling Protein complex
Deposited on 2018-01-09, released 2018-04-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-25, with a file datestamp of 2018-04-20.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c2ya1, d6c2ya2, d6c2ya3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c2yb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6c2yg_
  • Heterogens: EJS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6c2yA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
    shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprapvvelskvplvqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c2yA (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
    kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtlavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkesp
    ffrsldwqmvflqkyppplipprtkgiklldsdqelyrnfpltiserwqqevaetvfdti
    naetdrlearkkaknkqlgedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewr
    gegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrday
    reaqqlvqrvpkmknkp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6c2yB (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c2yB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlkgnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftght
    gdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafatg
    sddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadr
    agvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >6c2yG (G:)
    hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
    pasenpfrekkffsail
    

    Sequence, based on observed residues (ATOM records): (download)
    >6c2yG (G:)
    asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre