PDB entry 6bw8
View 6bw8 on RCSB PDB site
Description: Mcl-1 complexed with small molecules
Class: apoptosis
Keywords: Mcl-1 inhibitor, cancer, structure-based design, drug discovery, APOPTOSIS
Deposited on
2017-12-14, released
2018-01-31
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-04, with a file datestamp of
2019-11-29.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
Species: Homo sapiens [TaxId:9606]
Gene: MCL1, BCL2L3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6bw8a_ - Chain 'B':
Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
Species: Homo sapiens [TaxId:9606]
Gene: MCL1, BCL2L3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6bw8b_ - Chain 'C':
Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
Species: Homo sapiens [TaxId:9606]
Gene: MCL1, BCL2L3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6bw8c_ - Chain 'D':
Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
Species: Homo sapiens [TaxId:9606]
Gene: MCL1, BCL2L3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6bw8d_ - Heterogens: ECM
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6bw8A (A:)
addelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg
Sequence, based on observed residues (ATOM records): (download)
>6bw8A (A:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6bw8B (B:)
addelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg
Sequence, based on observed residues (ATOM records): (download)
>6bw8B (B:)
delyrqsleiisrylreqatgakdpmgrsgatsrkaletlrrvgdgvqrnhetafqgmlr
kldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaes
itdvlvrtkrdwlvkqrgwdgfveffhv
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6bw8C (C:)
addelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg
Sequence, based on observed residues (ATOM records): (download)
>6bw8C (C:)
delyrqsleiisrylreqatgakkpmgratsrkaletlrrvgdgvqrnhetafqgmlrkl
dikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesit
dvlvrtkrdwlvkqrgwdgfveffh
- Chain 'D':
Sequence, based on SEQRES records: (download)
>6bw8D (D:)
addelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg
Sequence, based on observed residues (ATOM records): (download)
>6bw8D (D:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh