PDB entry 6bvl

View 6bvl on RCSB PDB site
Description: Ras:SOS:Ras in complex with a small molecule activator
Class: signaling protein
Keywords: Ras, SOS, inhibitor, ONCOPROTEIN, Protein-protein complex, MAPK, SIGNALING PROTEIN
Deposited on 2017-12-13, released 2018-10-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-29, with a file datestamp of 2019-05-24.
Experiment type: XRAY
Resolution: 1.7500000000000002 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6bvla_
  • Chain 'B':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-481)
      • expression tag (0)
    Domains in SCOPe 2.08: d6bvlb1, d6bvlb2
  • Chain 'C':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • expression tag (0)
    Domains in SCOPe 2.08: d6bvlc1, d6bvlc2
  • Heterogens: GNP, MG, EBY, FMT, GOL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6bvlA (A:)
    gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
    gqeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
    laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bvlA (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6bvlB (B:)
    gqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
    rtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqp
    vqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiar
    dngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpsel
    vgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqe
    lnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinp
    pcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrve
    sdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn
    pr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6bvlB (B:)
    gqmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltt
    yrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvl
    nvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkianitfqss
    pptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkein
    spnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsa
    mnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltni
    lkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpm
    gnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6bvlC (C:)
    gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
    gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
    laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh