PDB entry 6brc

View 6brc on RCSB PDB site
Description: Crystal Structure of the Human CAMKK2B in complex with AP26113-analog (ALK-IN-1)
Class: transferase/transferase inhbitor
Keywords: transferase, protein kinase domain, Structural Genomics, Structural Genomics Consortium, SGC, Transferase Inhibitor Complex, TRANSFERASE-TRANSFERASE INHBITOR complex
Deposited on 2017-11-30, released 2017-12-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calcium/calmodulin-dependent protein kinase kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMKK2, CAMKKB, KIAA0787
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RR4 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.06: d6brca1, d6brca2
  • Chain 'B':
    Compound: Calcium/calmodulin-dependent protein kinase kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMKK2, CAMKKB, KIAA0787
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d6brcb_
  • Heterogens: E5J, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6brcA (A:)
smqlnqytlkdeigkgsygvvklaynendntyyamkvlskkklirqagfprrppprgtrp
apggciqprgpieqvyqeiailkkldhpnvvklvevlddpnedhlymvfelvnqgpvmev
ptlkplsedqarfyfqdlikgieylhyqkiihrdikpsnllvgedghikiadfgvsnefk
gsdallsntvgtpafmapeslsetrkifsgkaldvwamgvtlycfvfgqcpfmderimcl
hskiksqalefpdqpdiaedlkdlitrmldknpesrivvpeiklhpwvtrh

    Sequence, based on observed residues (ATOM records): (download) 
    >6brcA (A:)
smqlnqytlkdeigkgsygvvklaynendntyyamkvlskkklirqieqvyqeiailkkl
dhpnvvklvevlddpnedhlymvfelvnqgpvmevptlkplsedqarfyfqdlikgieyl
hyqkiihrdikpsnllvgedghikiadfgvsnefkgsdallsntvgtpafmapeslsetr
kifsgkaldvwamgvtlycfvfgqcpfmderimclhskiksqalefpdqpdiaedlkdli
trmldknpesrivvpeiklhpwvtr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6brcB (B:)
smqlnqytlkdeigkgsygvvklaynendntyyamkvlskkklirqagfprrppprgtrp
apggciqprgpieqvyqeiailkkldhpnvvklvevlddpnedhlymvfelvnqgpvmev
ptlkplsedqarfyfqdlikgieylhyqkiihrdikpsnllvgedghikiadfgvsnefk
gsdallsntvgtpafmapeslsetrkifsgkaldvwamgvtlycfvfgqcpfmderimcl
hskiksqalefpdqpdiaedlkdlitrmldknpesrivvpeiklhpwvtrh

    Sequence, based on observed residues (ATOM records): (download) 
    >6brcB (B:)
qlnqytlkdeigkgsygvvklaynendntyyamkvlskkklirqvyqeiailkkldhpnv
vklvevlddpnedhlymvfelvnqgpvmevptlkplsedqarfyfqdlikgieylhyqki
ihrdikpsnllvgedghikiadfgvsnefkgsdallsntvgtpafmapeslsetrkifsg
kaldvwamgvtlycfvfgqcpfmderimclhskiksqalefpdqpdiaedlkdlitrmld
knpesrivvpeiklhpwvtr