PDB entry 6bn5

View 6bn5 on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2
Class: hydrolase/hydrolase inhibitor
Keywords: SHP2, PTPN11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-11-16, released 2017-12-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (285)
    Domains in SCOPe 2.07: d6bn5a1, d6bn5a2, d6bn5a3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (285)
    Domains in SCOPe 2.07: d6bn5b1, d6bn5b2
  • Heterogens: DZJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6bn5A (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bn5A (A:)
wfhpnitgveaenllltrgvdgsflarpsdftlsvravthikiqntgdyydlyggekfat
laelvqyymehielkyplncadptserwfhghlsgkeaekllthgsflvrepgdfvlsvr
tgdskvthvmircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqpnttrin
aaiesrvrelsqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlh
sdyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpd
eyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpg
gvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpkt
iqmvrsqrsgmvqteaqyrfiymavqhy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6bn5B (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bn5B (B:)
rrwfhpnitgveaenllltrgvdgsflarpspgdftlsvrrngavthikiqntgdyydly
ggekfatlaelvqyymehelkyplncadperwfhghlslltekgkhgsflvrepgdfvls
vrtgkvthvmircqelkydvgggerfdsltdlvehykknpmvtvlqlkqplnttrinaae
iesrvrelskqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlhs
dyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpde
yalkeygvmrvrnvkesaahdytlrelklskvgqtertvwqyhfrtwpdhgvpsdpggvl
dfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqm
vrsqrsgmvqteaqyrfiymavqhyiet