PDB entry 6bmu

View 6bmu on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP244
Class: hydrolase/hydrolase inhibitor
Keywords: SHP2, PTPN11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-11-15, released 2018-01-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-03-28, with a file datestamp of 2018-03-23.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bmua1, d6bmua2, d6bmua3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bmub1, d6bmub2, d6bmub3
  • Heterogens: 5OD, DZV, PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6bmuA (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bmuA (A:)
srrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyyd
lyggekfatlaelvqyymehhgqlkgdvielkyplncadptserwfhghleklltekgkh
gsflvrespgdfvlsvrtgskvthvmircqelkydvgggerfdsltdlvehykknpmvet
lgtvlqlkqplnttrinaaeiesrvrelsklqgfweefetlqqqeckllysrkegqrqen
knknryknilpfdhtrvvlhdgdppvsdyinaniimppkksyiatqgclqntvndfwrmv
fqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklsk
vgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigr
tgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6bmuB (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bmuB (B:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqldvielkyplncadptserwfhghlsgaeklltekg
khgsflvrepgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvet
lgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenk
nknryknilpfdhtrvvlhvsdyinaniimppkksyiatqgclqntvndfwrmvfqensr
vivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgnt
ertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfiv
idilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl