PDB entry 6bmr

View 6bmr on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP244
Class: hydrolase/hydrolase inhibitor
Keywords: SHP2, PTPN11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-11-15, released 2018-01-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-03-28, with a file datestamp of 2018-03-23.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bmra1, d6bmra2, d6bmra3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6bmrb1, d6bmrb2, d6bmrb3
  • Heterogens: DZV, PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6bmrA (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bmrA (A:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkengdvielkyplncadptserwfhghlsgkeae
klltekgkhgsflvresqpgdfvlsvrtgskvthvmircqelkydvgggerfdsltdlve
hykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklqgfweefetlqqqecklly
srkegqrqenknknryknilpfdhtrvvlhdgdppvsdyinaniimpeksyiatqgclqn
tvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdy
tlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvv
vhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiym
avqhyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6bmrB (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >6bmrB (B:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkengdvielkyplncadptserwfhghlsgkeaek
lltekgkhgsflvrespgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehyk
knpmvetlgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrke
gqrqenknknryknilpfdhtrvvlhvsdyinaniimppkksyiatqgclqntvndfwrm
vfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelkls
kvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagig
rtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyiet
l