PDB entry 6bib
View 6bib on RCSB PDB site
Description: 1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: protease, norovirus, Norwalk virus, antiviral inhibitors, triazole-based macrocyclic inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2017-11-01, released
2018-11-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-11, with a file datestamp of
2019-12-06.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 3C-like protease
Species: Norwalk virus [TaxId:524364]
Gene: ORF1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6biba1, d6biba2 - Chain 'B':
Compound: 3C-like protease
Species: Norwalk virus [TaxId:524364]
Gene: ORF1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6bibb1, d6bibb2 - Heterogens: DW7, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6bibA (A:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale
Sequence, based on observed residues (ATOM records): (download)
>6bibA (A:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6bibB (B:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale
Sequence, based on observed residues (ATOM records): (download)
>6bibB (B:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa