PDB entry 6b0t

View 6b0t on RCSB PDB site
Description: Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule
Class: protein binding
Keywords: Metastaic cancers, Small-molecule inhibitors, actin-bundling, Domain rotation, PROTEIN BINDING
Deposited on 2017-09-15, released 2018-04-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0ta1, d6b0ta2, d6b0ta3, d6b0ta4
  • Chain 'B':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0tb1, d6b0tb2, d6b0tb3, d6b0tb4
  • Chain 'C':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0tc1, d6b0tc2, d6b0tc3, d6b0tc4
  • Chain 'D':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0td1, d6b0td2, d6b0td3, d6b0td4
  • Chain 'E':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0te1, d6b0te2, d6b0te3, d6b0te4
  • Chain 'F':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FSCN1, FAN1, HSN, SNL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b0tf1, d6b0tf2, d6b0tf3, d6b0tf4
  • Heterogens: C7V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tA (A:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tB (B:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tC (C:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tD (D:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tE (E:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6b0tF (F:)
    aeavqiqfglincgnkyltaeafgfkvnasasslkkkqiwtleqppdeagsaavclrshl
    grylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtv
    spaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqry
    svqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkat
    kvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkca
    frthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaas
    vetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynik
    dstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvd
    paslwey