PDB entry 6asq

View 6asq on RCSB PDB site
Description: Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor
Class: chaperone/inhibitor
Keywords: Grp94, Hsp90, Inhibitor, CHAPERONE-INHIBITOR complex
Deposited on 2017-08-25, released 2018-04-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmin
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: HSP90B1, GRP94, TRA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41148 (Start-218)
      • linker (222)
    • Uniprot P41148 (223-232)
    Domains in SCOPe 2.07: d6asqa_
  • Chain 'B':
    Compound: Endoplasmin
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: HSP90B1, GRP94, TRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6asqb_
  • Heterogens: VC4, PE8, PEG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6asqA (A:)
    slreksekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenala
    gneeltvkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqs
    tseligqfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgtti
    tlvlkeeasdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn
    

    Sequence, based on observed residues (ATOM records): (download)
    >6asqA (A:)
    ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
    vkikcdkeknllhvtdtgvgmtreelvknlgtiakgtseflnkmtestseligqfgvgfy
    saflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdyle
    ldtiknlvkkysqfinfpiyvwssktgktvwdwelmn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6asqB (B:)
    slreksekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenala
    gneeltvkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqs
    tseligqfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgtti
    tlvlkeeasdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn
    

    Sequence, based on observed residues (ATOM records): (download)
    >6asqB (B:)
    ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
    vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteastseligqfgvg
    fysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdy
    leldtiknlvkkysqfinfpiyvwssktktvwdwelmn