PDB entry 6asp

View 6asp on RCSB PDB site
Description: Structure of Grp94 with methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, a Grp94-selective inhibitor and promising therapeutic lead for treating myocilin-associated glaucoma
Class: chaperone/inhibitor
Keywords: Grp94, Hsp90, Inhibitor, Glaucoma, CHAPERONE-INHIBITOR complex
Deposited on 2017-08-25, released 2018-04-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmin
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: HSP90B1, GRP94, TRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aspa_
  • Chain 'B':
    Compound: Endoplasmin
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: HSP90B1, GRP94, TRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aspb_
  • Heterogens: P33, GOL, V2C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6aspA (A:)
slreksekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenala
gneeltvkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqs
tseligqfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgtti
tlvlkeeasdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aspA (A:)
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiagtseflnkmtestseligqfgvgfys
aflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdylel
dtiknlvkkysqfinfpiyvwssktktvwdwelmn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6aspB (B:)
slreksekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenala
gneeltvkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqs
tseligqfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgtti
tlvlkeeasdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aspB (B:)
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmtestseligqfgvgf
ysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdyl
eldtiknlvkkysqfinfpiyvwssktktvwdwelmn