PDB entry 6ajc

View 6ajc on RCSB PDB site
Description: Crystal structure of Trypanosoma cruzi cytosolic isocitrate dehydrogenase in complex with NADP+, isocitrate and ca2+
Class: oxidoreductase
Keywords: Trypanosoma cruzi, metabolism, isocitrate dehydrogenase, OXIDOREDUCTASE
Deposited on 2018-08-27, released 2019-08-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-28, with a file datestamp of 2019-08-23.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajca_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajcb_
  • Chain 'C':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajcc_
  • Chain 'D':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajcd_
  • Chain 'E':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajce_
  • Chain 'F':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajcf_
  • Chain 'G':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4E4L7 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d6ajcg_
  • Chain 'H':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053506925.319
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ajch_
  • Heterogens: NAP, CA, ICT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcA (A:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ajcB (B:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

    Sequence, based on observed residues (ATOM records): (download) 
    >6ajcB (B:)
sqkivagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvdaa
haikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprlv
ttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmgm
yntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykka
giwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgrt
veaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllekv
vvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcC (C:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcD (D:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcE (E:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcF (F:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajcG (G:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6ajcH (H:)
sqkikvagtvveldgdemtrviwkmikeelifpfldvpieyydlgmenrdktddqvtvda
ahaikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprl
vttwkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmg
myntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykk
agiwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgr
tveaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllek
vvvstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski

    Sequence, based on observed residues (ATOM records): (download) 
    >6ajcH (H:)
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aikkhgvgvkcatitpdearvrefnlkqmwkspngtirnilggtvfrepimcknvprlvt
twkhpivigrhafgdqyratdlvvngpgtfeihfvpesggaaqvqkvfdfksggvlmgmy
ntdesikdfakscfeyalskkwplylstkntilkrydgrfkdifaemykasyeadykkag
iwyehrliddmvayamkseggyvwacknydgdvqsdsvaqgfgslglmtsvlmspdgrtv
eaeaahgtvtrhyrqhqkgeetstnpvasifawtrglmhrgkldqneklvqfsmllekvv
vstieagfmtkdlaicikgmnhvtrsdylntqefihklademrkayerski