PDB entry 6ajb

View 6ajb on RCSB PDB site
Description: Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADH, alpha-ketoglutarate and ca2+
Class: oxidoreductase
Keywords: Trypanosoma brucei, glycosome, metabolism, isocitrate dehydrogenase, OXIDOREDUCTASE
Deposited on 2018-08-27, released 2019-08-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-08-28, with a file datestamp of 2019-08-23.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q387G0 (0-End)
      • engineered mutation (0)
    Domains in SCOPe 2.07: d6ajba_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q387G0 (0-End)
      • engineered mutation (0)
    Domains in SCOPe 2.07: d6ajbb_
  • Chain 'C':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ajbc_
  • Chain 'D':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q387G0 (0-412)
      • engineered mutation (0)
    Domains in SCOPe 2.07: d6ajbd_
  • Heterogens: NAD, CA, AKG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ajbA (A:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqkskv

    Sequence, based on observed residues (ATOM records): (download) 
    >6ajbA (A:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ajbB (B:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqkskv

    Sequence, based on observed residues (ATOM records): (download) 
    >6ajbB (B:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqks

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ajbC (C:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqkskv

    Sequence, based on observed residues (ATOM records): (download) 
    >6ajbC (C:)
tgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtveaayaikk
hgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprlvttwkk
pvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmgmyntdd
sirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfktcgifye
hrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgktvevea
ahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrledviiati
eagamtedlaicikgeknvvradylntdefidavsqrlkvamqkskv

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ajbD (D:)
snkisatgvlveldgdemtrviwkkiketlifpfvnvpieyydlsmenrdktedrvtvea
ayaikkhgvgvkcatitpdearvkefnlkkmwrspngtirtilggtvfrepiicsnvprl
vttwkkpvvigrhafgdqysatdavvkepgtfemrfipanggepkvykvfdyksggvmmg
myntddsirdfarscfefalarkwplylstkntilkhydgrfkdifaemykalyetkfkt
cgifyehrliddmvahcmrseggyvwacknydgdvqsdslaqgfgslgmmtsilmtpdgk
tveveaahgtvtrhyrdyqkgketstnpvasifawtralahrarvdnnntlleftqrled
viiatieagamtedlaicikgeknvvradylntdefidavsqrlkvamqkskv