PDB entry 6a7a

View 6a7a on RCSB PDB site
Description: AKR1C1 complexed with new inhibitor with novel scaffold
Class: oxidoreductase
Keywords: Aldo-keto reductase family 1 member C1, 20-alpha-hydroxysteroid Dehydrogenase, alpha-HSD, OXIDOREDUCTASE
Deposited on 2018-07-02, released 2019-07-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-07-03, with a file datestamp of 2019-06-28.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C1
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C1, DDH, DDH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6a7aa_
  • Heterogens: NAP, 9S0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6a7aA (A:)
    msyyhhhhhhegvrtmdskyqcvklndghfmpvlgfgtyapaevpkskaleatklaieag
    frhidsahlynneeqvglairskiadgsvkredifytsklwcnshrpelvrpalerslkn
    lqldyvdlylihfpvsvkpgeevipkdengkilfdtvdlcatweavekckdaglaksigv
    snfnrrqlemilnkpglkykpvcnqvechpyfnqrklldfckskdivlvaysalgshree
    pwvdpnspvlledpvlcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfe
    fqltseemkaidglnrnvryltldifagppnypfsdey
    

    Sequence, based on observed residues (ATOM records): (download)
    >6a7aA (A:)
    qcvklndghfmpvlgfgtyapaevpkskaleatklaieagfrhidsahlynneeqvglai
    rskiadgsvkredifytsklwcnshrpelvrpalerslknlqldyvdlylihfpvsvkpg
    eevipkdengkilfdtvdlcatweavekckdaglaksigvsnfnrrqlemilnkpglkyk
    pvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlledpvlcala
    kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidglnrnvry
    ltldifagppnypfsdey