PDB entry 5zxh

View 5zxh on RCSB PDB site
Description: The structure of MT189-tubulin complex
Class: structural protein
Keywords: tubulin complex, STRUCTURAL PROTEIN
Deposited on 2018-05-21, released 2019-05-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-05-22, with a file datestamp of 2019-05-17.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBA1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5zxha1, d5zxha2
  • Chain 'B':
    Compound: Tubulin beta-2B chain
    Species: Bos taurus [TaxId:9913]
    Gene: TUBB2B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6B856 (0-End)
      • engineered mutation (169)
      • engineered mutation (315)
    Domains in SCOPe 2.07: d5zxhb1, d5zxhb2
  • Chain 'C':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBA1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5zxhc1, d5zxhc2
  • Chain 'D':
    Compound: Tubulin beta-2B chain
    Species: Bos taurus [TaxId:9913]
    Gene: TUBB2B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6B856 (0-End)
      • engineered mutation (169)
      • engineered mutation (315)
    Domains in SCOPe 2.07: d5zxhd1, d5zxhd2
  • Chain 'E':
    Compound: Stathmin-4
    Species: Rattus norvegicus [TaxId:10116]
    Gene: STMN4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5zxhe_
  • Chain 'F':
    Compound: tubulin tyrosine ligase
    Species: Gallus gallus [TaxId:9031]
    Gene: TTL
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1BQ43 (0-377)
      • expression tag (378-383)
    Domains in SCOPe 2.07: d5zxhf1, d5zxhf2
  • Heterogens: 9LX, GTP, MG, CA, GDP, MES, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5zxhA (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegee
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhA (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5zxhB (B:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
    lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhB (B:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsqyraltvpeltqqmfdsknmmaacd
    prhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkms
    atfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqq
    yqda
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5zxhC (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegee
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhC (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5zxhD (D:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
    lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhD (D:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfaplltvpeltqqmfdsknmmaacdprhgry
    ltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkmsatfign
    staiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqqyqdata
    d
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5zxhE (E:)
    madmevielnkctsgqsfevilkppsfdgvpefnaslprrrdpsleeiqkkleaaeerrk
    yqeaellkhlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamler
    lqekdkhaeevrknkelkeeasr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhE (E:)
    mevielnkctsgqsfevilkppdpsleeiqkkleaaeerrkyqeaellkhlaekrehere
    viqkaieennnfikmakeklaqkmesnkenreahlaamlerlqekdkhaeevrknkelke
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5zxhF (F:)
    mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
    lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptnlktpvapaqngirhli
    nntrtderevflaaynrrregregnvwiakssagakgegilisseaselldfideqgqvh
    viqkylekplllepghrkfdirswvlvdhlyniylyregvlrtssepynsanfqdktchl
    tnhciqkeysknygryeegnemffeefnqylmdalnttlensillqikhiirsclmciep
    aistkhlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcqgivdvaissvfp
    ladtgqktsqptsifiklhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5zxhF (F:)
    mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
    lvnyyrgadklcrkaslvkliktspelsesctwfpesyviypgnvwiaksgilisseahv
    iqkylekplllepghrkfdirswvlvdhlyniylyregvlrtssepynsanfqdktchlt
    nhciqknygryeegnemffeefnqylmdalnttlensillqikhiirsclmciepaistk
    hlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcqgivdvaissvfplasif
    iklhhhhhh