PDB entry 5zwh
View 5zwh on RCSB PDB site
Description: Covalent bond formation between histidine of Vitamin D receptor (VDR) and a full agonist having an ene-ynone group via conjugate addition reaction
Class: hormone
Keywords: HORMONE covalent modifier transcription factor VitaminD3 enone Michael addition electrophile, HORMONE
Deposited on
2018-05-15, released
2018-07-18
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-08-08, with a file datestamp of
2018-08-03.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.23
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Vitamin D3 receptor
Species: Rattus norvegicus [TaxId:10116]
Gene: Vdr, Nr1i1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5zwha_ - Chain 'C':
Compound: 13-meric peptide from DRIP205 NR2 BOX peptide
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: 9KX, 9N9, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5zwhA (A:)
gshmgspnsplkdslrpklseeqqhiiailldahhktydptyadfrdfrppvrmdgstgs
vtldlsplsmlphladlvsysiqkvigfakmipgfrdltsddqivllkssaievimlrsn
qsftmddmswdcgsqdykydvtdvskaghtlelieplikfqvglkklnlheeehvllmai
civspdrpgvqdaklveaiqdrlsntlqtyircrhpppgshqlyakmiqkladlrslnee
hskqyrslsfqpensmkltplvlevfgneis
Sequence, based on observed residues (ATOM records): (download)
>5zwhA (A:)
klseeqqhiiailldahhktydptyadfrdfrppvrlsmlphladlvsysiqkvigfakm
ipgfrdltsddqivllkssaievimlrsnqsftmddmswdcgsqdykydvtdvskaghtl
elieplikfqvglkklnlheeehvllmaicivspdrpgvqdaklveaiqdrlsntlqtyi
rcrhpppgshqlyakmiqkladlrslneehskqyrslsfqpensmkltplvlevfgn
- Chain 'C':
No sequence available.