PDB entry 5z5u

View 5z5u on RCSB PDB site
Description: The first bromodomain of BRD4 with compound BDF-2254
Class: transcription/inhibitor
Keywords: BRD4, Inhibitor, Complex, PROTEIN BINDING, TRANSCRIPTION-INHIBITOR complex
Deposited on 2018-01-20, released 2019-01-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d5z5ua1, d5z5ua2
  • Heterogens: 96U, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5z5uA (A:)
    mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
    tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
    elpte
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z5uA (A:)
    mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
    tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
    elpt