PDB entry 5z30

View 5z30 on RCSB PDB site
Description: The crystal structure of the nucleosome containing a cancer-associated histone H2A.Z R80C mutant
Class: DNA binding protein/DNA
Keywords: DNA binding, nucleus, chromatin formation, histone fold, histone, nucleosome, chromatin, DNA BINDING PROTEIN-DNA complex
Deposited on 2018-01-05, released 2018-07-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-07-18, with a file datestamp of 2018-07-13.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone H3.1
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5z30b_
  • Chain 'C':
    Compound: histone h2a.z
    Species: Homo sapiens [TaxId:9606]
    Gene: H2AFZ, H2AZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0S5
      • engineered mutation (83)
    Domains in SCOPe 2.07: d5z30c_
  • Chain 'D':
    Compound: Histone H2B type 1-J
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H2BJ, H2BFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5z30d_
  • Chain 'E':
    Compound: Histone H3.1
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5z30f_
  • Chain 'G':
    Compound: histone h2a.z
    Species: Homo sapiens [TaxId:9606]
    Gene: H2AFZ, H2AZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C0S5
      • engineered mutation (83)
    Domains in SCOPe 2.07: d5z30g_
  • Chain 'H':
    Compound: Histone H2B type 1-J
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H2BJ, H2BFR
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: DNA (146-mer)
    Species: Homo sapiens [TaxId:9606]
  • Chain 'J':
    Compound: DNA (146-mer)
    Species: Homo sapiens [TaxId:9606]
  • Heterogens: CL, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5z30B (B:)
    gshmsgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrg
    vlkvflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z30B (B:)
    niqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrktvtam
    dvvyalkrqgrtlygfg
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5z30C (C:)
    gshmaggkagkdsgkaktkavsrsqraglqfpvgrihrhlksrttshgrvgataavysaa
    ileyltaevlelagnaskdlkvkcitprhlqlairgdeeldslikatiagggviphihks
    ligkkgqqktv
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z30C (C:)
    kavsrsqraglqfpvgrihrhlksrttshgrvgataavysaaileyltaevlelagnask
    dlkvkcitprhlqlairgdeeldslikatiagggviphihkslig
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5z30D (D:)
    gshmpepaksapapkkgskkavtkaqkkdgkkrkrsrkesysiyvykvlkqvhpdtgiss
    kamgimnsfvndiferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtk
    avtkytsak
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z30D (D:)
    srkesysiyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstits
    reiqtavrlllpgelakhavsegtkavtkytsa
    

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5z30F (F:)
    gshmsgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrg
    vlkvflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z30F (F:)
    hrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehak
    rktvtamdvvyalkrqgrtlygfg
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5z30G (G:)
    gshmaggkagkdsgkaktkavsrsqraglqfpvgrihrhlksrttshgrvgataavysaa
    ileyltaevlelagnaskdlkvkcitprhlqlairgdeeldslikatiagggviphihks
    ligkkgqqktv
    

    Sequence, based on observed residues (ATOM records): (download)
    >5z30G (G:)
    gkaktkavsrsqraglqfpvgrihrhlksrttshgrvgataavysaaileyltaevlela
    gnaskdlkvkcitprhlqlairgdeeldslikatiagggviphihkslig
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.