PDB entry 5ywi

View 5ywi on RCSB PDB site
Description: Crystal structure of Arabidopsis thaliana HPPD Truncated mutant complexed with NTBC
Class: oxidoreductase
Keywords: 4-hydroxyphenylpyruvate dioxygenase, nitisinone, Type 1 Tyrosinemia, drug discovery, OXIDOREDUCTASE
Deposited on 2017-11-29, released 2019-01-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-01-16, with a file datestamp of 2019-01-11.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 4-hydroxyphenylpyruvate dioxygenase
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: HPD, PDS1, At1g06570, F12K11.9
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ywia1, d5ywia2
  • Heterogens: CO, NTD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ywiA (A:)
    fvrknpksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasyllt
    sgdlrflftapyspslsageikptttasipsfdhgscrsffsshglgvravaievedaes
    afsisvangaipssppivlneavtiaevklygdvvlryvsykaedtekseflpgferved
    assfpldygirrldhavgnvpelgpaltyvagftgfhqfaeftaddvgtaesglnsavla
    sndemvllpinepvhgtkrksqiqtylehnegaglqhlalmsedifrtlremrkrssigg
    fdfmpsppptyyqnlkkrvgdvlsddqikeceelgilvdrddqgtllqiftkplgdrpti
    fieiiqrvgcmmkdeegkayqsggcggfgkgnfselfksieeyektleakqlvg
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ywiA (A:)
    npksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasylltsgdl
    rflftapyspslsageikptttasipsfdhgscrsffsshglgvravaievedaesafsi
    svangaipssppivlneavtiaevklygdvvlryvsykeflpgfervedassfpldygir
    rldhavgnvpelgpaltyvagftgfhqfaesglnsavlasndemvllpinepvhgtksqi
    qtylehnegaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvl
    sddqikeceelgilvdddqgtllqiftkplgdrptifieiiqrvggcggfgkgnfselfk
    si