PDB entry 5yqo

View 5yqo on RCSB PDB site
Description: Crystal structure of Sirt2 in complex with selective inhibitor L5C
Class: hydrolase/hydrolase inhibitor
Keywords: NAD-dependent deacetylase sirtuin-2, Inhibitor, Complex, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-11-07, released 2018-10-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-17, with a file datestamp of 2018-10-12.
Experiment type: XRAY
Resolution: 1.48 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nad-dependent protein deacetylase sirtuin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT2, SIR2L, SIR2L2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8IXJ6 (5-305)
      • expression tag (0-4)
    Domains in SCOPe 2.07: d5yqoa1, d5yqoa2
  • Heterogens: ZN, L5C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5yqoA (A:)
    gasgserlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnleky
    hlpypeaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnid
    tleriagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkp
    divffgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkeka
    gqsdpflgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrreha
    sidaqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >5yqoA (A:)
    gasgserlldeltlegvarymqsercrrviclvgagistsagipdfrspstpypeaifei
    syfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagleqe
    dlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgeslpa
    rffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflggmd
    fdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs