PDB entry 5ylj

View 5ylj on RCSB PDB site
Description: Crystal structure of T2R-TTL-Millepachine complex
Class: structural protein
Keywords: colchicine binding domain, tubulin inhibitor, tublin, Millepachine, STRUCTURAL PROTEIN
Deposited on 2017-10-17, released 2018-04-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-07-11, with a file datestamp of 2018-07-06.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBA1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ylja1, d5ylja2
  • Chain 'B':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBB2B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5yljb1, d5yljb2
  • Chain 'C':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBA1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5yljc1, d5yljc2
  • Chain 'D':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Gene: TUBB2B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5yljd1, d5yljd2
  • Chain 'E':
    Compound: Stathmin-4
    Species: Rattus norvegicus [TaxId:10116]
    Gene: STMN4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ylje_
  • Chain 'F':
    Compound: tubulin tyrosine ligase
    Species: Gallus gallus [TaxId:9031]
    Gene: TTL
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1BQ43 (0-377)
      • expression tag (378-379)
    Domains in SCOPe 2.08: d5yljf1, d5yljf2, d5yljf3
  • Heterogens: GTP, MG, CA, GOL, GDP, MES, 8X0, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5yljA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5yljB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeeegedea

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqda

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5yljC (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljC (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5yljD (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeeegedea

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljD (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfaplltvpeltqqmfdsknmmaacdprhgry
ltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkmsatfign
staiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqqyqdata
d

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5yljE (E:)
madmevielnkctsgqsfevilkppsfdgvpefnaslprrrdpsleeiqkkleaaeerrk
yqeaellkhlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamler
lqekdkhaeevrknkelkeeasr

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljE (E:)
mevielnkctsgqsfevilkppsdpsleeiqkkleaaeerrkyqeaellkhlaekreher
eviqkaieennnfikmakeklaqkmesnkenreahlaamlerlqekdkhaeevrknkelk
e

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5yljF (F:)
mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptnlktpvapaqngirhli
nntrtderevflaaynrrregregnvwiakssagakgegilisseaselldfideqgqvh
viqkylekplllepghrkfdirswvlvdhlyniylyregvlrtssepynsanfqdktchl
tnhciqkeysknygryeegnemffeefnqylmdalnttlensillqikhiirsclmciep
aistkhlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcqgivdvaissvfp
ladtgqktsqptsifiklhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5yljF (F:)
mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptderevflaaynrrregr
egnvwialisseaselldfideqgqvhviqkylekplllepghrkfdirswvlvdhlyni
ylyregvlrtssepynsanfqdktchltnhciqknygryeegnemffeefnqylmdalnt
tlensillqikhiirsclmciepaistkhlhyqsfqlfgfdfmvdeelkvwlievngapa
caqklyaelcqgivdvaissvfplatsifiklhh