PDB entry 5yfn

View 5yfn on RCSB PDB site
Description: Human isocitrate dehydrogenase 1 bound with isocitrate
Class: oxidoreductase
Keywords: IDH1, isocitrate, NADPH regeneration, CYTOSOLIC PROTEIN, OXIDOREDUCTASE
Deposited on 2017-09-21, released 2017-10-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874 (7-End)
      • expression tag (0-6)
    Domains in SCOPe 2.07: d5yfna1, d5yfna2
  • Chain 'B':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874 (7-End)
      • expression tag (0-6)
    Domains in SCOPe 2.07: d5yfnb1, d5yfnb2
  • Heterogens: MG, ICT, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5yfnA (A:)
nlyfqsmmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatn
dqvtkdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaii
ckniprlvsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfe
egggvamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydk
qyksqfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmts
vlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkela
ffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqak
l

    Sequence, based on observed residues (ATOM records): (download) 
    >5yfnA (A:)
nlyfqsmmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatn
dqvtkdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaii
ckniprlvsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfe
egggvamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydk
qyksqfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmts
vlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkela
ffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5yfnB (B:)
nlyfqsmmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatn
dqvtkdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaii
ckniprlvsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfe
egggvamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydk
qyksqfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmts
vlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkela
ffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqak
l

    Sequence, based on observed residues (ATOM records): (download) 
    >5yfnB (B:)
nlyfqsmmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatn
dqvtkdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaii
ckniprlvsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfe
egggvamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydk
qyksqfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmts
vlvcpdgktveaeaahgtvttnpiasifawtrglahrakldnnkelaffanaleevsiet
ieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa