PDB entry 5y8p

View 5y8p on RCSB PDB site
Description: Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + 3-Hydroxy propionate (3-HP)
Class: oxidoreductase
Keywords: 3-Hydroxy acid Dehydrogenase, Enzyme substrate interactions, Mechanism of enzyme action, OXIDOREDUCTASE
Deposited on 2017-08-21, released 2018-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable 3-hydroxyisobutyrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: mmsB, Rv0751c, MTV041.25c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5y8pa1, d5y8pa2
  • Chain 'B':
    Compound: Probable 3-hydroxyisobutyrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: mmsB, Rv0751c, MTV041.25c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNY5 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d5y8pb1, d5y8pb2, d5y8pb3
  • Heterogens: GOL, 9ON, 3OH, AKR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5y8pA (A:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrarada

    Sequence, based on observed residues (ATOM records): (download) 
    >5y8pA (A:)
mttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaeadv
vitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvsg
gvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqqi
aiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfstal
mnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5y8pB (B:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrarada

    Sequence, based on observed residues (ATOM records): (download) 
    >5y8pB (B:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlra