PDB entry 5y8n

View 5y8n on RCSB PDB site
Description: Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD + L-serine
Class: oxidoreductase
Keywords: 3-Hydroxy acid Dehydrogenase, Enzyme substrate interactions, Mechanism of enzyme action, OXIDOREDUCTASE
Deposited on 2017-08-21, released 2018-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable 3-hydroxyisobutyrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: mmsB, Rv0751c, MTV041.25c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5y8na1, d5y8na2
  • Chain 'B':
    Compound: Probable 3-hydroxyisobutyrate dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: mmsB, Rv0751c, MTV041.25c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNY5 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d5y8nb1, d5y8nb2, d5y8nb3
  • Heterogens: NAD, SER, GOL, AKR, 9ON, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5y8nA (A:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrarada

    Sequence, based on observed residues (ATOM records): (download) 
    >5y8nA (A:)
ttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaeadvv
itmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvsgg
vkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqqia
iaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfstalm
nkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5y8nB (B:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlrarada

    Sequence, based on observed residues (ATOM records): (download) 
    >5y8nB (B:)
mmttiaflglgnmgapmsanlvgaghvvrgfdpaptaasgaaahgvavfrsapeavaead
vvitmlptgevvrrcytdvlaaarpatlfidsstisvtdarevhalaeshgmlqldapvs
ggvkgaaaatlafmvggdestlrrarpvlepmagkiihcgaagagqaakvcnnmvlavqq
iaiaeafvlaeklglsaqslfdvitgatgncwavhtncpvpgpvptspanndfkpgfsta
lmnkdlglamdavaatgataplgshaadiyakfaadhadldfsavihtlra