PDB entry 5xve

View 5xve on RCSB PDB site
Description: Crystal structure of human USP2 C276S mutant in complex with ubiquitin
Class: hydrolase
Keywords: ubiquitin specific protease for anticancer target, HYDROLASE
Deposited on 2017-06-27, released 2018-02-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 1.24 Å
R-factor: N/A
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: USP2, UBP41
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75604
      • conflict (18)
    Domains in SCOPe 2.07: d5xvea_
  • Chain 'B':
    Compound: Ubiquitin-40S ribosomal protein S27a
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5xveb_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5xveA (A:)
    mnsksaqglaglrnlgntsfmnsilqclsntrelrdyclqrlymrdlhhgsnahtalvee
    fakliqtiwtsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvt
    lrpksnpenldhlpddekgrqmwrkyleredsrigdlfvgqlkssltctdcgycstvfdp
    fwdlslpiakrgypevtlmdcmrlftkedvldgdekptccrcrgrkrcikkfsiqrfpki
    lvlhlkrfsesrirtsklttfvnfplrdldlrefasentnhavynlyavsnhsgttmggh
    ytaycrspgtgewhtfndssvtpmsssqvrtsdayllfyelasppsrmlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5xveA (A:)
    aqglaglrnlgntsfmnsilqclsntrelrdyclqrlymrdlhhgsnahtalveefakli
    qtiwtsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvtlenld
    hlpddekgrqmwrkyleredsrigdlfvgqlkssltctdcgycstvfdpfwdlslpiakr
    gypevtlmdcmrlftkedvldgdekptccrcrgrkrcikkfsiqrfpkilvlhlkrfses
    rirtsklttfvnfplrdldlrefasentnhavynlyavsnhsgttmgghytaycrspgtg
    ewhtfndssvtpmsssqvrtsdayllfyela
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5xveB (B:)
    mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
    iqkestlhlvlrlrgg