PDB entry 5xdk

View 5xdk on RCSB PDB site
Description: Crystal structure of EGFR 696-1022 T790M in complex with CO-1686
Class: transferase
Keywords: EGFR, T790M, inhibitor, TRANSFERASE
Deposited on 2017-03-28, released 2017-12-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (4-End)
      • engineered mutation (98)
    Domains in SCOPe 2.08: d5xdka_
  • Heterogens: 8JC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5xdkA (A:)
gamggeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlps
ptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >5xdkA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelratspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpdmddvv
dadeyli