PDB entry 5x8w

View 5x8w on RCSB PDB site
Description: Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain.
Class: transcription/inhibitor
Keywords: Inhibitor, Binary Complex, Nuclear Receptor, TRANSCRIPTION-INHIBITOR complex
Deposited on 2017-03-03, released 2017-06-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Uncharacterized protein
    Species: Nomascus leucogenys [TaxId:61853]
    Gene: RORC
    Database cross-references and differences (RAF-indexed):
    • Uniprot G1RH57
      • engineered mutation (208)
      • engineered mutation (212)
    Domains in SCOPe 2.07: d5x8wa_
  • Chain 'B':
    Compound: Nuclear receptor coactivator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA1, BHLHE74, SRC1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5x8wA (A:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8wA (A:)
yaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahh
lteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyg
gmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlq
ynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpplyk
elfs

  • Chain 'B':
    No sequence available.