PDB entry 5x8q
View 5x8q on RCSB PDB site
Description: Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.
Class: transferase/ihibitor
Keywords: Inhibitor, Ternary Complex, Nuclear Receptor, TRANSFERASE-IHIBITOR complex
Deposited on
2017-03-03, released
2017-06-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-06-28, with a file datestamp of
2017-06-23.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
- Uniprot P51449
- engineered mutation (208)
- engineered mutation (212)
Domains in SCOPe 2.08: d5x8qa_ - Chain 'B':
Compound: Nuclear receptor corepressor 2
Species: Homo sapiens [TaxId:9606]
Gene: NCOR2, CTG26
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
- Uniprot P51449
- engineered mutation (208)
- engineered mutation (212)
Domains in SCOPe 2.08: d5x8qc_ - Chain 'D':
Compound: Nuclear receptor corepressor 2
Species: Homo sapiens [TaxId:9606]
Gene: NCOR2, CTG26
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
- Uniprot P51449
- engineered mutation (208)
- engineered mutation (212)
Domains in SCOPe 2.08: d5x8qe_ - Chain 'F':
Compound: Nuclear receptor corepressor 2
Species: Homo sapiens [TaxId:9606]
Gene: NCOR2, CTG26
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
- Uniprot P51449
- engineered mutation (208)
- engineered mutation (212)
Domains in SCOPe 2.08: d5x8qg_ - Chain 'H':
Compound: Nuclear receptor corepressor 2
Species: Homo sapiens [TaxId:9606]
Gene: NCOR2, CTG26
Database cross-references and differences (RAF-indexed):
- Heterogens: 82R, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5x8qA (A:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk
Sequence, based on observed residues (ATOM records): (download)
>5x8qA (A:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5x8qC (C:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk
Sequence, based on observed residues (ATOM records): (download)
>5x8qC (C:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv
- Chain 'D':
No sequence available.
- Chain 'E':
Sequence, based on SEQRES records: (download)
>5x8qE (E:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk
Sequence, based on observed residues (ATOM records): (download)
>5x8qE (E:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv
- Chain 'F':
No sequence available.
- Chain 'G':
Sequence, based on SEQRES records: (download)
>5x8qG (G:)
eapyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerc
ahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffeg
kyggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkve
qlqynlelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpivvqaafpp
lykelfstetespvglsk
Sequence, based on observed residues (ATOM records): (download)
>5x8qG (G:)
slteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlt
eaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggm
elfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqyn
lelafhhhlckthrqsilaklppagklaslcsqhverlqifqhlhpiv
- Chain 'H':
No sequence available.