PDB entry 5x6v

View 5x6v on RCSB PDB site
Description: Crystal structure of human heteroheptameric complex
Class: protein binding
Keywords: Ragulator Rag GTPase complex, scaffold, roadblock, lysosome, mTOR signaling, cell growth, PROTEIN BINDING
Deposited on 2017-02-23, released 2017-12-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 2.02 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Ragulator complex protein LAMTOR3
  Species: Homo sapiens [TaxId:9606]
  Gene: LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9UHA4 (4-End)
  Domains in SCOPe 2.08: d5x6va_
• Chain 'B':
  Compound: Ragulator complex protein LAMTOR2
  Species: Homo sapiens [TaxId:9606]
  Gene: LAMTOR2, MAPBPIP, ROBLD3, HSPC003
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9Y2Q5 (0-124)
  Domains in SCOPe 2.08: d5x6vb_
• Chain 'C':
  Compound: Ragulator complex protein LAMTOR5
  Species: Homo sapiens [TaxId:9606]
  Gene: LAMTOR5, HBXIP, XIP
  Database cross-references and differences (RAF-indexed):
  • Uniprot O43504 (0-90)
• Chain 'D':
  Compound: Ragulator complex protein LAMTOR4
  Species: Homo sapiens [TaxId:9606]
  Gene: LAMTOR4, C7orf59
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q0VGL1
• Chain 'E':
  Compound: Ragulator complex protein LAMTOR1
  Species: Homo sapiens [TaxId:9606]
  Gene: LAMTOR1, C11orf59, PDRO, PP7157
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q6IAA8 (Start-122)
    • engineered mutation (59)
• Chain 'F':
  Compound: Ras-related GTP-binding protein A
  Species: Homo sapiens [TaxId:9606]
  Gene: RRAGA
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7L523
• Chain 'G':
  Compound: Ras-related GTP-binding protein C
  Species: Mus musculus [TaxId:10090]
  Gene: RRAGC
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99K70 (1-End)
• Heterogens: NA, ACT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >5x6vA (A:)
  mgssaddlkrflykklpsveglhaivvsdrdgvpvikvandnapehalrpgflstfalat
  dqgsklglsknksiicyyntyqvvqfnrlplvvsfiasssantglivslekelaplfeel
  rqvvevs
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5x6vA (A:)
  addlkrflykklpsveglhaivvsdrdgvpvikvandnapehalrpgflstfalatdqgs
  klglsknksiicyyntyqvvqfnrlplvvsfiasssantglivslekelaplfeelrqvv
  e
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5x6vB (B:)
  mlrpkaltqvlsqantggvqstlllnnegsllaysgygdtdarvtaaiasniwaaydrng
  nqafnednlkfilmdcmegrvaitrvanlllcmyaketvgfgmlkakaqalvqyleeplt
  qvaas
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  No sequence available.