PDB entry 5x69

View 5x69 on RCSB PDB site
Description: Human thymidylate synthase with a fragment bound in the dimer interface
Class: transferase
Keywords: methyltransferase, TRANSFERASE
Deposited on 2017-02-21, released 2017-06-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69b_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69c_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69d_
  • Chain 'E':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69e_
  • Chain 'F':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5x69f_
  • Heterogens: 7ZC, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5x69A (A:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69A (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5x69B (B:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69B (B:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5x69C (C:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69C (C:)
pphgelqylgqiqhilrcgvrkdtgtlsvfgmqaryslrdefpllttkrvfwkgvleell
wfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdm
esdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnsels
cqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiql
qreprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5x69D (D:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69D (D:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5x69E (E:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69E (E:)
pphgelqylgqiqhilrcgvrkdgtlsvfgmqaryslrdefpllttkrvfwkgvleellw
fikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdme
sdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselsc
qlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlq
reprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5x69F (F:)
smpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x69F (F:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt