PDB entry 5x4w

View 5x4w on RCSB PDB site
Description: Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition
Class: transferase
Keywords: methyltransferase, TRANSFERASE
Deposited on 2017-02-14, released 2017-06-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (191)
    Domains in SCOPe 2.07: d5x4wa_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5x4wA (A:)
smpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvf
gmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdfld
slgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriim
cawnprdlplmklppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiah
itglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqie
gynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5x4wA (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysg
qgvdqlqrvidtiktnpddrriimcawnprdlplmklppchalcqfyvvnselscqlyqr
sgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprp
fpklrilrkvekiddfkaedfqiegynphptikmem