PDB entry 5x2s

View 5x2s on RCSB PDB site
Description: Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5.
Class: transport protein
Keywords: Hemoglobin, Allostery, Allosteric proteins, Oxygen binding, Bezafibrate, TRANSPORT PROTEIN
Deposited on 2017-02-02, released 2017-09-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sa_
  • Chain 'B':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sb_
  • Chain 'C':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sc_
  • Chain 'D':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sd_
  • Chain 'E':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2se_
  • Chain 'F':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sf_
  • Chain 'G':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sg_
  • Chain 'H':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sh_
  • Chain 'I':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2si_
  • Chain 'J':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sj_
  • Chain 'K':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sk_
  • Chain 'L':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5x2sl_
  • Heterogens: HNI, HEM, PEM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5x2sA (A:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sA (A:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5x2sB (B:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sB (B:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5x2sC (C:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sC (C:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5x2sD (D:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sD (D:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5x2sE (E:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sE (E:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5x2sF (F:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sF (F:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5x2sG (G:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sG (G:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >5x2sH (H:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sH (H:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >5x2sI (I:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sI (I:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >5x2sJ (J:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sJ (J:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >5x2sK (K:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sK (K:)
    lspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgkk
    vadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpav
    hasldkflasvstvltskyr
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >5x2sL (L:)
    vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
    kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
    eftppvqaayqkvvagvanalahkyh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5x2sL (L:)
    hltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkvk
    ahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgke
    ftppvqaayqkvvagvanalahkyh