PDB entry 5wxt

View 5wxt on RCSB PDB site
Description: Crystal structure of uPA-S195A in complex with S2444
Class: hydrolase/hydrolase inhibitor
Keywords: Serine proteases, uPA, pepetide inhibitors, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-01-08, released 2018-07-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-07-11, with a file datestamp of 2018-07-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'U':
    Compound: urokinase-type plasminogen activator chain b
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00749 (0-End)
      • engineered mutation (120)
      • engineered mutation (143)
      • engineered mutation (197)
    Domains in SCOPe 2.07: d5wxtu_
  • Heterogens: 7YR, HOH

PDB Chain Sequences:

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >5wxtU (U:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslispcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
alpsmyndpqfgtsceitgfgkeqstdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdaggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtkeenglal

    Sequence, based on observed residues (ATOM records): (download) 
    >5wxtU (U:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslispcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
alpsmyndpqfgtsceitgfgkeqstdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdaggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irsht