PDB entry 5wvo

View 5wvo on RCSB PDB site
Description: Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3
Class: signaling protein/transferase
Keywords: DNA methylation, Ubiquitination, SIGNALING PROTEIN-TRANSFERASE complex
Deposited on 2016-12-28, released 2017-11-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: Rps27a, Uba80, Ubcep1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62979 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.08: d5wvoa_
  • Chain 'B':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: Rps27a, Uba80, Ubcep1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62979 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.08: d5wvob_
  • Chain 'C':
    Compound: DNA (cytosine-5)-methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DNMT1, AIM, CXXC9, DNMT
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Histone H3.1
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68431
      • engineered mutation (17)
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5wvoA (A:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5wvoB (B:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.