PDB entry 5wrn

View 5wrn on RCSB PDB site
Description: Human thymidylate synthase complexed with dCMP
Class: transferase
Keywords: Complex, nucleotide, TRANSFERASE
Deposited on 2016-12-02, released 2016-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-12-14, with a file datestamp of 2016-12-09.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrna1, d5wrna2
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrnb1, d5wrnb2
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrnc1, d5wrnc2
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrnd1, d5wrnd2
  • Chain 'E':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrne1, d5wrne2
  • Chain 'F':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5wrnf1, d5wrnf2
  • Heterogens: DC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wrnA (A:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnA (A:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5wrnB (B:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnB (B:)
mpphgelqylgqiqhilrcgvrkdtgtlsvfgmqaryslrdefpllttkrvfwkgvleel
lwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrd
mesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnsel
scqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiq
lqreprpfpklrilrkvekiddfkaedfqiegynphptikme

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5wrnC (C:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnC (C:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5wrnD (D:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnD (D:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5wrnE (E:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnE (E:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5wrnF (F:)
mpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
leellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfga
eyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvv
nselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiep
lkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >5wrnF (F:)
mpphgelqylgqiqhilrcgvrkdgtlsvfgmqaryslrdefpllttkrvfwkgvleell
wfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdm
esdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnsels
cqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiql
qreprpfpklrilrkvekiddfkaedfqiegynphpt