PDB entry 5wg5

View 5wg5 on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG224061
Class: transferase
Keywords: beta-adrenergic receptor kinase 1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, TRANSFERASE
Deposited on 2017-07-13, released 2017-12-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-27, with a file datestamp of 2017-12-22.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wg5a1, d5wg5a2, d5wg5a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wg5b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63212
      • engineered mutation (67)
    Domains in SCOPe 2.07: d5wg5g_
  • Heterogens: ZSO, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5wg5A (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
    shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprspvvelskvplvqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5wg5A (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
    kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgppdlfqpyieei
    cqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrkadt
    gkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfildl
    mnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehghvri
    sdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghspfrq
    hktkdkheidrmtlvelpdsfspelrsllegllqrdvnrrlgclgrgaqevkespffrsl
    dwqmvflqkyppplippvnaadafdtkgiklldsdqelyrnfpltiserwqqevaetvfd
    tinaetdrlearkkaknkqldyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewr
    gegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrday
    reaqqlvqrvpkmknkp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5wg5B (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >5wg5B (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5wg5G (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffsail
    

    Sequence, based on observed residues (ATOM records): (download)
    >5wg5G (G:)
    tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekk
    ffs