PDB entry 5wg4

View 5wg4 on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG257284
Class: TRANSFERASE/Signaling Protein
Keywords: TRANSFERASE-Signaling Protein complex
Deposited on 2017-07-13, released 2017-12-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-27, with a file datestamp of 2017-12-22.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5wg4a1, d5wg4a2, d5wg4a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5wg4b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5wg4g_
  • Heterogens: AFV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wg4A (A:)
madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
vpkmknkprspvvelskvplvqrgsangl

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg4A (A:)
killpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeeik
kyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpyi
eeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrk
adtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfi
ldlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehgh
vrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghsp
frqhktkdkheidrmtltvelpdsfspelrsllegllqrdvnrrlgclgrgaqevkespf
frsldwqmvflqkyppplipprgevnaadatkgiklldsdqelyrnfpltiserwqqeva
etvfdtinaetdrlearkkaknkqlgdyalgkdcimhgymskmgnpfltqwqrryfylfp
nrlewrgeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkel
rdayreaqqlvqrvpkmknkp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5wg4B (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg4B (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5wg4G (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg4G (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek