PDB entry 5wg3

View 5wg3 on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG258748
Class: Transferase/Signaling Protein
Keywords: Transferase-Signaling Protein complex
Deposited on 2017-07-13, released 2017-12-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-01-17, with a file datestamp of 2018-01-12.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wg3a1, d5wg3a2, d5wg3a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wg3b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wg3g_
  • Heterogens: AFM, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wg3A (A:)
madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
vpkmknkprspvvelskvplvqrgsangl

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg3A (A:)
kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
pfrtkdkheidrmtltvelpdsfspelrsllegllqrdvnrrlgclgrgaqevkespffr
sldwqmvflqkyppplipprgevnaadaedtkgiklldsdqelyrnfpltiserwqqeva
etvfdtinaetdrlearkkaknedyalgkdcimhgymskmgnpfltqwqrryfylfpnrl
ewrgeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrda
yreaqqlvqrvpkmknkp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5wg3B (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg3B (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5wg3G (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >5wg3G (G:)
asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre